Norco contains a combination of acetaminophen and hydrocodone. Hydrocodone is an opioid pain medication. An opioid is sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.

Norco is used to relieve moderate to moderately severe pain.

Norco may also be used for purposes not listed in this medication guide.

Important information

Hydrocodone can slow or stop your breathing. Never use Norco in larger amounts, or for longer than prescribed. Narcotic pain medicine may be habit-forming, even at regular doses. Never share Norco with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

Do not use Norco if you have used a MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

Stop taking Norco and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Before taking this medicine

You should not use Norco if you are allergic to acetaminophen (Tylenol) or hydrocodone, or if you have recently used alcohol, sedatives, tranquilizers, or other narcotic medications.

Do not use Norco if you have taken a MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Some medicines can interact with hydrocodone and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take medicine for depression, mental illness, Parkinson’s disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

You should not use this medicine if you have:

  • severe asthma or breathing problems; or
  • a blockage in your stomach or intestines.

To make sure Norco is safe for you, tell your doctor if you have ever had:

  • breathing problems, sleep apnea;
  • liver disease;
  • a drug or alcohol addiction;
  • kidney disease;
  • a head injury or seizures;
  • urination problems; or
  • problems with your thyroid, pancreas, or gallbladder.
  • Side effects requiring immediate medical attention

    Along with its needed effects, acetaminophen / hydrocodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / hydrocodone:

    More common

    Incidence not known

    • Back, leg, or stomach pains
    • black, tarry stools
    • bleeding gums
    • blood in the urine or stools
    • blood in vomit
    • bluish lips or skin
    • chills
    • choking
    • cough
    • dark urine
    • decrease in the frequency of urination
    • decrease in urine volume
    • difficult or troubled breathing
    • difficulty in passing urine (dribbling)
    • difficulty with swallowing
    • fast heartbeat
    • fever
    • fever with or without chills
    • general body swelling
    • general feeling of tiredness or weakness
    • headache
    • hoarseness
    • irregular, fast or slow, or shallow breathing
    • light-colored stools
    • loss of appetite
    • lower back or side pain
    • nausea
    • nosebleeds
    • not breathing
    • painful or difficult urination
    • pale or blue lips, fingernails, or skin
    • pinpoint red spots on the skin
    • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    • severe or continuing stomach pain
    • skin rashhives, or itching
    • sore throat
    • sore tongue
    • sores, ulcers, or white spots on the lips or in the mouth
    • tightness in the chest
    • unable to speak
    • unusual bleeding or bruising
    • unusual tiredness or weakness
    • upper right abdominal or stomach pain
    • vomiting
    • yellow eyes and skin

    Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / hydrocodone:

    Symptoms of overdose

    • Bloody or cloudy urine
    • change in consciousness
    • chest pain or discomfort
    • cold and clammy skin
    • decreased awareness or responsiveness
    • extreme drowsiness
    • general feeling of discomfort or illness
    • increased sweating
    • irregular heartbeat
    • lightheadedness, dizziness, or fainting
    • loss of consciousness
    • no blood pressure or pulse
    • no muscle tone or movement
    • not breathing
    • severe sleepiness
    • slow or irregular heartbeat
    • stopping of heart
    • sudden decrease in the amount of urine
    • unpleasant breath odor