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Actoplus Met (Pioglitazone/Metformin)
Actoplus Met is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.
How to use
Use Actoplus Met as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with Actoplus Met . Talk to your pharmacist if you have questions about this information.
Take Actoplus Met by mouth with meals.
Take Actoplus Met on a regular schedule to get the most benefit from it. Taking Actoplus Met at the same times each day will help you remember to take it.
Continue to take Actoplus Met even if you feel well. Do not miss any doses.
Drug Class and Mechanism
Actoplus Met is a biguanide and thiazolidinedione antidiabetic combination. It works by decreasing the amount of sugar the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.
If you miss a dose of Actoplus Met , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Store this medicine at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted.
Do NOT use Actoplus Met if:
you are allergic to any ingredient in Actoplus Met
you have type 1 diabetes
you have moderate to severe heart failure
you have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated
you have had a stroke or a recent heart attack, or you are in shock
you are 80 years old or more and have not had a kidney function test
you will be having surgery or certain lab procedures
you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Actoplus Met . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a history of heart problems (eg, heart failure), abnormal liver function tests, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, eye or vision problems (eg, macular degeneration), bladder cancer, or lactic acidosis
if you have fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia, or if you are dehydrated
if you have an infection, fever, recent injury, or moderate to severe burns
if you have a history of bone fracture, weak bones (eg, osteoporosis), or low calcium intake
if you drink alcohol or have a history of alcohol abuse
if you will be having surgery or certain lab procedures
if you take a beta-blocker (eg, propranolol)
Some MEDICINES MAY INTERACT with Actoplus Met . Tell your health care provider if you are taking any other medicines, especially any of the following:
Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of Actoplus Met ‘s side effects
Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (eg, glipizide), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased
Gemfibrozil because it may increase the risk of Actoplus Met ‘s side effects
Rifampin because it may decrease Actoplus Met ‘s effectiveness, resulting in high blood sugar
Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may be increased by Actoplus Met
Possible Side Effects
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Cold-like symptoms; diarrhea; headache; indigestion; mild weight gain; nausea; stomach upset.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; bone pain; chest pain or discomfort; dark urine; difficult or painful urination; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; pale stools; persistent loss of appetite; severe or persistent headache, nausea, or vomiting; shortness of breath; slow or irregular heartbeat; sudden unexplained weight gain; swelling of the hands, ankles, or feet; unusual stomach pain or discomfort; unusual drowsiness; unusual tiredness or weakness; yellowing of the eyes or skin.
If you have any questions about Actoplus Met , please talk with your doctor, pharmacist, or other health care provider.
Actoplus Met is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
If using Actoplus Met for an extended period of time, obtain refills before your supply runs out.
Actos is used to control high blood sugar in type 2 diabetes (non-insulin-dependent diabetes mellitus). This form of the illness is usually caused by inability of the body to respond correctly to insulin: either the body does not produce enough insulin or the cells ignore the insulin. Insulin is the natural hormone that helps to transfer sugar out of the blood and into the cells, where it is metabolized to energy. Actos works by improving the response of the body to insulin, rather than increasing its insulin output. Actos also reduces the production of unneeded sugar in the liver.
It is possible to use Actos (and rosiglitazone maleate as well) alone or together with insulin injections or other oral diabetes medications such as glipizide, glyburide, metformin hydrochloride.
Dosage and directions
Take this medication by mouth, with or without food, usually one time a day. Follow all directions of your health care advisor as dosage is based on your medical condition, possible reaction to therapy, and can be corrected if you are treated by other anti-diabetic medications. Take this drug each time the same day as this way you will get the most benefit from it. Regularly monitor blood glucose levels. It may take up to 2 to 3 months before the full benefit is realized. Take all other medications for diabetes according to recommendations of your doctor.
Before taking Actos, tell your doctor or pharmacist if you are allergic to it; if you are allergic to other “glitazones” (such as rosiglitazone, troglitazone); or if you have any other types of allergy. Do not use Actos if you have certain medical conditions. Before starting treatment with Actos, notify you doctor or pharmacist if you have: type 1 diabetes (insulin-dependent diabetes), heart failure (acute congestive heart failure) either newly diagnosed or worsening, dangerously high blood glucose (diabetic ketoacidosis), liver dysfunctions. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (chronic congestive heart failure), liver problems, fluid in your lungs, swelling (edema), anemia. Extremely low or high blood sugar levels may cause blurred vision, dizziness, or drowsiness; be cautious engaging in activities requiring alertness for example driving or operating machinery. Limit alcohol as much as possible when you are treated with this medication because it can increase the risk of developing hypoglycemia. If you have fever, infection, injury or surgery, it may complicate controlling of your blood sugar. Consult your doctor, as you may need correction of dose or a change in your medication may be required. Women with certain fertility problems may have changes in the menstrual cycle (ovulation) taking this medication. Consult your doctor or pharmacist about prescription of reliable contraception while you are taking Actos. This medication should be used in pregnant women only in life threating conditions. Discuss its risks and benefits with your physician. If you are pregnant your doctor may substitute insulin for Actos. Follow all instructions carefully. There are no reports whether this drug excretes with breast milk. Breastfeeding is not advised while using this drug. Before starting breastfeeding consult your physician.
Possible side effects
Actos side effects include rapid heartbeat, sweating, confusion, blurred vision, headache, numbness or tingling of the mouth, weakness,shakiness, dizziness, tiredness, paleness and sudden hunger.
If you miss a dose, take it as soon as you remember unless just a few hours remained till your next dose. Skip the missed dose and return to the dosing schedule in case it is near the time of the next dose. Do not double the dose to make up the dose you missed.
Seek emergency medical attention if you think you have taken too much of this medicine. You may have signs of low blood sugar, such as hunger, weakness, dizziness, headache, irritability, drowsiness, fainting, sweating, confusion, tremors, fast heartbeat, seizure (convulsions), or coma.
Inform your health care advisor if you are taking any other anti-diabetic medications (insulin, metformin, or sulfonylureas such as glyburide), herbal/natural products (fenugreek, ginseng, gymnema). This medication is able to decrease the effectiveness of certain contraceptives which may result in pregnancy. Take care about additional form of reliable birth control while using Actos. Do not begin or discontinue an intake of any medicine without doctor or pharmacist approval.
Store at room temperature in a tight container, away from moisture and humidity.
We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.
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